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Major obstetric haemorrhage: monitoring with thromboelastography, laboratory analyses or both?

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The role of fibrinogen in trauma-induced coagulopathy

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Hämostaseologie 2014 34 29-39

Transfusion and hematologic variables after fibrinogen or platelet transfusion in valve replacement surgery: preliminary data of purified lyophilized human fibrinogen concentrate versus conventional transfusion

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Alternatives to blood transfusion

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Blood: a precious resource

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Challenges in the management of the blood supply

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Combination of recombinant factor VIIa and fibrinogen corrects clot formation in primary immune thrombocytopenia at very low platelet counts

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Concepts of blood transfusion in adults

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Effect of a fixed-ratio (1:1:1) transfusion protocolversus laboratory-results–guided transfusion in patients with severe trauma: a randomized feasibility trial

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CMAJ 2013 185(12) E583-9

Effects of Fibrinogen Concentrate After Shock/Resuscitation: A Comparison Between In Vivo Microvascular Clot Formation and Thromboelastometry

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Crit Care Med 2013 41(11) e301-8

Effects of Fibrinogen Concentrate as First-line Therapy during Major Aortic Replacement Surgery.A Randomized, Placebo-controlled Trial

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Efficacy and safety of fibrinogen concentrate in trauma patients-a systematic review.

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Estimation of plasma fibrinogen levels based on hemoglobin, base excess and Injury Severity Score upon emergency room admission

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Fast interpretation of thromboelastometry in non-cardiac surgery: reliability in patients with hypo-, normo-, and hypercoagulability

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Fibrinogen as a therapeutic target for bleeding: a review of critical levels and replacement therapy

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Fibrinogen concentrate and cryoprecipitate but not fresh frozen plasma correct low fibrinogen concentrations following in vitro haemodilution

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Fibrinogen concentrate in bleeding patients (Review)

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Fibrinogen depletion in trauma: early, easy to estimate and central to trauma-induced coagulopathy

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Critical Care 2013 17 (5) 190

Fibrinogen Supplementation in Cardiac Surgery: Where Are We Now and Where Are We Going?

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J Cardiothorac Vasc Anesth. 2013 27(1) 1-4

Fresh frozen plasma: the most commonly prescribed hemostatic agent

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J Thromb Haemost 2013 11(10) 1794–1799

Goal-Directed Coagulation Management in the Perioperative Period of Cardiac Surgery

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Hyperfibrinolysis diagnosed by rotational thromboelastometry in a case of suspected amniotic fluid embolism.

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Hyperfibrinolysis is common in out-of-hospital cardiac arrest. Results from a prospective observational thromboelastometry study

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Resuscitation 2013 84(4) 454-9

Impact of fibrinogen concentrate alone or with prothrombin complex concentrate (+/− fresh frozen plasma) on plasma fibrinogen level and fibrin-based clot strength (FIBTEM) in major trauma: a retrospective study

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Impact of Fibrinogen Levels on Outcomes after Acute Injury in Patients Requiring a Massive Transfusion

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INVITED COMMENTARY: All we ever wanted to know about perioperative bleeding

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Management of bleeding and coagulopathy following major trauma: an updated European guideline

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Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology.

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Mechanisms of trauma-induced coagulopathy

© American Society of Hematology
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Hematology Am Soc Hematol Educ Program. 2013 2013 660-3

Perioperative coagulation management during cardiac surgery.

Weber CF, Klages M, Zacharowski K.
Curr Opin Anaesthesiol. 2013 26(1) 60-4

Perioperative factor concentrate therapy

© Oxford University Press (abstract)
K. A. Tanaka, S. Esper, D. Bolliger
Br J Anaesth. 2013 111(S1) i35-i49

Potential value of pharmacological protocols in trauma

© LWW (abstract)
Schöchl H., Christoph J. Schlimp, Wolfgang Voelckel
Curr Opin Anesthesiol 2013 26(2) 221-9

Practical application of point-of-care coagulation testing to guide treatment decisions in trauma

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Schöchl H, Voelckel W, Grassetto A, Schlimp CJ.
J Trauma Acute Care Surg 2013 74 (6) 1587-98

Prehospital detection of traumatic coagulopathy.

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Transfusion 2013 53 Suppl 1 48S-51S

Prevention and treatment of trauma induced coagulopathy (TIC). An intended protocol from the Italian trauma update research group

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Substrates of Factor XIII-A: roles in thrombosis and wound healing

© 2013 Biochemical Society
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Clinical Science 2013 124 123–137

The early use of fibrinogen, prothrombin complex concentrate, and recombinant-activated factor VIIa in massive bleeding

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Transfusion 2013 53 Suppl 1 91S-95S

The exclusive use of coagulation factor concentrates enables reversal of coagulopathy and decreases transfusion rates in patients with major blunt trauma

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Injury 2013 44(2) 209-16

The exclusive use of coagulation factor concentrates enables reversal of coagulopathy and decreases transfusion rates in patients with major blunt trauma

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The Incidence and Magnitude of Fibrinolytic Activation in Trauma Patients

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Thrombin Generation Capacity of Prothrombin Complex Concentrate in an In Vitro Dilutional Model

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Plos ONE 2013 8(5) e64100

Time course of haemostatic effects of fibrinogen concentrate administration in aortic surgery

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C. Solomon; C. Hagl; N. Rahe-Meyer
Br. J. Anaesth. 2013

Time course of haemostatic effects of fibrinogen concentrate administration in aortic surgery

© Oxford University Press
C. Solomon, C. Hagl, N. Rahe-Meyer
Br J Anaesth. 2013 110(6) 947-56

Utility of interim ROTEM values of clot strength, A5 and A1, in predicting final assessment of coagulation status in severely injured battle patients

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Injury 2013 44, Issue 5 593-599

A comparative evaluation of rotation thromboelastometry and standard coagulation tests in hemodilution-induced coagulation changes after cardiac surgery.

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Transfusion 2012 52(1) 14-22

Acute traumatic coagulopathy.

© LWW (abstract)
Daniel Frith et al.
Curr Opin Anaesthesiol. 2012 25(2) 229-34

Admission Rapid Thrombelastography Can Replace Conventional Coagulation Tests in the Emergency Department: experience with 1974 consecutive trauma patients.

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Ann Surg. 2012 256(3) 476-86

An assessment of thromboelastometry to monitor blood coagulation and guide transfusion support in liver transplantation

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TRANSFUSION 2012 52(9) 1989-98

Association between fibrinogen level and severity of postpartum haemorrhage: secondary analysis of a prospective trial

© Oxford University Press
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Br. J. Anaesth. (2012) 2012 108(6) 984-989

Audit on the usage of plasma derived ⁄ recombinant coagulation factor concentrates at a German University Hospital

© International Society of Blood Transfusion (abstract)
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Vox Sanguinis 2012 103(2) 122-9


© Edizioni Minerva Medica
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Minerva Anestesiol. 2012 78(12) 1357-64

Coagulation management

© LWW (abstract)
Oliver Grottke
Curr Opin Crit Care 2012 18(6) 641-6

Comparison of cryoprecipitate with fibrinogen concentrate for acquired hypofibrinogenaemia

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Transf Apheres Sci 2012 46(2) 159-62

Comparison of thromboelastometry (ROTEM) with standard plasmatic coagulation testing in paediatric surgery

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Br J Anaesth. 2012 108(1) 36-41

Comparison of Whole Blood Fibrin-Based Clot Tests in Thrombelastography and Thromboelastometry

© International Anesthesia Research Society
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Anesth Analg 2012 114(4) 721-30

Detection of tPA-Induced Hyperfibrinolysis in Whole Blood by RapidTEG, KaolinTEG, and Functional FibrinogenTEG in Healthy Individuals

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Clin Appl Thromb Hemost. 2012 18(6) 638-44

Early and individualized goal-directed therapy for trauma-induced coagulopathy

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Scand J Trauma Resusc Emerg Med. 2012 20 15

Effect of haematocrit on fibrin-based clot firmness in the FIBTEM test

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Blood Transfus 2012 20 01. Aug

Elevated prepartum fibrinogen levels are not associated with a reduced risk of postpartum hemorrhage

© Wiley/Blackwell Publishing
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J Thromb Haemost. 2012 10(7) 1451-3

Emerging treatment strategies for trauma-induced coagulopathy

© Wiley
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British Journal of Surgery 2012 99/suppl 1 40-50

Fibrinogen and Hemostasis: A Primary Hemostatic Target for the Management of Acquired Bleeding

© International Anesthesia Research Society
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Journal of anaesthesia and analgesia 2012 114 (2) 261-74

Fibrinogen as a Hemostatic Agent

© Thieme (abstract)
Sørensen B. et al
Semin Thromb Hemost 2012 38(03) 268-273

Fibrinogen concentrates for bleeding trauma patients: what is the evidence?

© Wiley (abstract)
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ISBT Science Series, 2012 7 177-182

Fibrinogen Concentrate Therapy Guided by Thromboelastometry as an Alternative to Fresh Frozen Plasma in Major Vascular Surgery

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Journal of Cardiothoracic and Vascular Anesthesia 2012 26 (4) 654-659

Fibrinogen function after severe burn injury

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Burns 2012 38(1) 77-82

Fibrinogen Levels during Trauma Hemorrhage, Response to Replacement Therapy and Association with Patient Outcomes

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Fibrinogen replacement therapy: a critical review of the literature

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Blood Transfus 2012 10 23-7

From Life-Blood Streaming to Hemostasis

© International Anesthesia Research Society
Richard B. Weiskopf
Anesth Analg 2012 114(2) 247-249

Haemostatic monitoring during postpartum haemorrhage and implications for management

© Oxford University Press
Solomon et al.
Br. J. Anaesth. 2012 109(6) 851-863

Haemostatic therapy in coronary artery bypass graft patients withdecreased platelet function: Comparison of fi brinogen concentrate with allogeneic blood products

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Improved point-of-care identification of hyperfibrinolysis is needed

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Pybus S1, MacCormac A, Houghton A, Martlew V, Thachil J.
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Is fresh-frozen plasma clinically effective? An update of a systematic review of randomized controlled trials

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Mobile Laboratory Unit: a disruptor solution for hemostasis management during major surgery. Usage in the context of face transplantation

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Monitoring Prohemostatic Treatment in Bleeding Patients

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Obstetric Hemorrhage and Coagulation: An Update. Thromboelastography, Thromboelastometry, and Conventional Coagulation Tests in the Diagnosis and Prediction of Postpartum Hemorrhage

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Obstet Gynecol Surv. 2012 67(7) 426-35.

Patient Blood Management: Clinical Hemotherapy and Hemostasis Management in Perioperative Settings

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Transfus Med Hemother 2012 39 57-58

Patient blood management in Europe

© Oxford University Press
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Br. J. Anaesth. 2012 109(1) 55-68

Perioperative course of FXlll in children undergoing major surgery

© Wiley/Blackwell Publishing (abstract)
Thorsten Haas, et al
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Prospective Longitudinal Study of Thromboelastography and Standard Hemostatic Laboratory Tests in Healthy Women During Normal Pregnancy

© International Anesthesia Research Society
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Anesth Analg 2012 115 890-898

Reduced clot-stability during the first 6 hours after aneurysmal subarachnoid haemorrhage – a prospective case-control study,

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Thrombosis Research 2012 129(5) e229-32

Reduction of Fresh Frozen Plasma Requirements by Perioperative Point-of-Care Coagulation Management with Early Calculated Goal-Directed Therapy

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Transfus Med Hemother 2012 39 104-113

Reproducibility of thrombelastometry (ROTEM ®): Point-of-care versus hospital laboratory performance

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Scand J Clin Lab Invest. 2012 72 313-317

Resuscitation and transfusion management in trauma patients: emerging concepts

© LWW (abstract)
Theusinger et al.
Curr Opin Crit Care 2012 18(6) 661-70

Rotational Thromboelastometry (ROTEM) - Based Coagulation Management in Cardiac Surgery and Major Trauma

© Elsevier (abstract)
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J Cardiothorac Vasc Anesth. 2012 26(6) 1983-93

ROTEM®-guided coagulation factor concentrate therapy in trauma: 2-year experience in Venice, Italy

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Strategies to preempt and reduce the use of blood products: an Australian perspective

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Curr Opin Anesthesiol 2012 25 66-73

Strategies to reduce the use of blood products: a US perspective

© LWW (abstract)
Shander and Javidroozi
Curr Opin Anesthesiol 2012 25 50-58

Supplementation of fibrinogen in acquired bleeding disorders: experience, evidence, guidelines, and licences

© Oxford University Press
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Br. J. Anaesth. 2012 109(2) 135-7

Surgical Outcomes and Transfusion of Minimal Amounts of Blood in the Operating Room

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ARCH SURG 2012 147(1) 55-56

Systematic review of the efficacy and safety of fibrinogen concentrate substitution in adults

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Acta Anaesthesiol Scand. 2012 56(5) 539-48

The acute coagulopathy of trauma: mechanisms and tools for risk stratification.

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Shock 2012 38(5) 450-8

The efficacy of fibrinogen concentrate compared with cryoprecipitate in major obstetric haemorrhage – an observational study

© LWW (abstract)
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Transfusion Medicine 2012 22 344 – 349

The FIB-PPH trial: fibrinogen concentrate as initial treatment for postpartum haemorrhage: study protocol for a randomised controlled trial

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Wikkelsoe at al.
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The Impact of Hematocrit on Fibrin Clot Formation Assessed by Rotational Thromboelastometry

© International Anesthesia Research Society
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Anesth Analg 2012 115(1) 16-21

THE PAPWORTH PLUG – successful use of high dose fibrinogen concentrate and platelet concentrate in potential life-threatening complication after cardiopulmonary bypass surgery in a patient with Type 2M Vicenza von Willebrand Disease

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Perfusion 2012 27 307 -310

Theragnostic performance of ex vivo testing of haemostatic intervention and clinical effect of recombinant factor VIIa and fibrinogen concentrate.

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Thrombosis Research 2012 129(5) e263-5

Thrombin generation in plasma from patients with cirrhosis supplemented with normal plasma: considerations on the efficacy of treatment with fresh-frozen plasma

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Intern Emerg Med 2012 7(2) 139-144

Thromboelastography and thromboelastometry and the management of intra-operative transfusion therapy in massively bleeding patients

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Blood Transfus. 2012 10(3) 400–401

Thromboelastography: might work in neonatology too?

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Thromboelastometry Based Early Goal-Directed Coagulation Management Reduces Blood Transfusion Requirements, Adverse Events, and Costs in Acute Type A Aortic Dissection: A Pilot Study

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Transfus Med Hemother 2012 39 121-128

Time to watch out for the bleeding trauma patient

© LWW (abstract)
Rolf Rossaint
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Trauma-associated hyperfibrinolysis

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Hämostaseologie 2012 32(1) 22-7

Viscoelastic clot strength predicts coagulation-related mortality within 15 minutes

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A comparison of fibrinogen measurement methods with fibrin clot elasticity assessed by thromboelastometry, before and after administration of fibrinogen concentrate in cardiac surgery patients

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Acquired type 2A von Willebrand syndrome caused by aortic valve disease corrects during valve surgery

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British Journal of Anaesthesia 2011 106(4) 494-500

Acute Traumatic Coagulopathy in Severe Injury: Incidence, Risk Stratification, and Treatment Options

© Deutsches Ärzteblatt International
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Deutsches Ärzteblatt International 2011 108(49) 827 -35

A national study of plasma use in critical care: clinical indications, dose and effect on prothrombin time

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Critical Care 2011 15 R108

Are the Point - of - Care Diagnostics MULTI PLATE and ROTEM Valid in the Setting o f High Concentrations of Heparin and Its Reversal With Protamine ?

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Journal of Cardiothoracic and Vascular Anesthesia 2011 25(6) 981-986

Assessment of coagulation in the obstetric population using ROTEM thromboelastometry

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Bleeding and management of coagulopathy.

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J Thorac Cardiovasc Surg. 2011 142(3) 662-7

Can RoTEMs analysis be applied for haemostatic monitoring in paediatric congenital heart surgery?

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Cardiology in the Young 2011 21 issue 6 pp 684 -691

Clinical effectiveness a systematic review of fresh frozen plasma compared with fibrinogen concentrate:

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Critical Care 2011 15 R 239

Clinical review: Prothrombin complex concentrates - evaluation of safety and thrombogenicity

© BioMed Central Ltd
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Comparison of Thrombelastometry with Simplified Acute Physiology Score II and Sequential Organ Failure Assessment Scores for the Prediction of 30-Day Survival: A Cohort Study

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Shock 2011 35 Issue 4 339 -242

Diagnostic Performance and Therapeutic Consequence of Thromboelastometry Activated by Kaolin versus a Panel of Specific Reagents

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Anaesthesiology 2011 115(2) 294-302

Efficacy of Prophylactic Low Dose of Tranexamic Acid in Spinal Fixation Surgery: A Randomized Clinical Trial

© LWW (abstract)
Majid R. Farrokhi, et al.
Journal of Neurosurgical Anaesthesiology 2011 23 (4) 290 -6

Emotional or evidence-based medicine: is there a moral tragedy in haemostatic therapy?

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Critical Care 2011 15(6) 462

Evaluation of a modified thromboelastography assay for the screening of von Willebrand disease

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Fibrin formation is more impaired than thrombin generation and platelets immediately following cardiac surgery

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Fibrinogen Availability and Coagulation Function after Hemorrhage and Resuscitation in Pigs

© National Center for Biotechnology Information
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Molecular Medicine 2011 17(7) 857-61

Fibrinogen concentrate in the treatment of severe bleeding after aortic aneurysm graft surgery

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Niels Rahe-Meyer
Thrombosis Research 2011 128 suppl 1: S17-9

FIBTEM provides early prediction of massive transfusion in trauma

© BioMed Central Ltd
Schöchl H, et al
Critical Care 2011 15 R265

First-line Therapy with Coagulation Factor Concentrates Combined with Point-of-Care Coagulation Testing Is Associated with Decreased Allogeneic Blood Transfusion in Cardiovascular Surgery A Retrospective, Single-center Cohort Study

Klaus Görlinger, et al.
Anaesthesiology 2011 115(6) 1179 -91

Functional definition and characterization of acute traumatic coagulopathy

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Crit Care Med 2011 39(12) 2652-8

High-dose tranexamic acid reduces blood loss in postpartum haemorrhage

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Hyperfibrinolysis diagnosed by rotational thromboelastometry (ROTEM) is associated with higher mortality in patients with severe trauma.

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Anesth Analg 2011 113(5) 1003-12

Increasing concentrations of prothrombin complex concentrate induce disseminated intravascular coagulation in a pig model of coagulopathy with blunt liver injury

© American Society of Hematology
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Intraoperative Thromboelastometry Is Associated with Reduced Transfusion Prevalence in Pediatric Cardiac Surgery

© International Anesthesia Research Society
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Intrarater and interrater variability of point of care coagulation testing using the ROTEM delta

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In Vitro impairment of whole blood coagulation and platelet function by hypertonic saline hydroxyethyl starch

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Letter to the Editor: Massive transfusion strategy or massive confusion in trauma with massive and ongoing bleeding

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More on Transfusion and Adverse Outcome: It's Time to Change

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New recommendations for thromboelastography reference ranges for pregnant women

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Observational study of fibrinoge nconcentrate in massive hemorrhage: evaluation of a multicenter register

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Patient blood management during cardiac surgery: Do we have enough evidence for clinical practice?

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Platelet function following trauma

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Preoperative Fibrinogen Plasma Concentration Is Associated With Perioperative Bleeding and Transfusion Requirements in Scoliosis Surgery

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Spine 2011 36 Issue 7 pp 549- 555

Prevalence and impact of abnormal ROTEM® assays in severe blunt trauma: results of the ‘Diagnosis and Treatment of Trauma-Induced Coagulopathy (DIA-TRE-TIC) study’

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Reference values for rotation thromboelastometry (ROTEM®) parameters following non-haemorrhagic deliveries. Correlations with standard haemostasis parameters

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Relative concentrations of haemostatic factors and cytokines in solvent detergent-treated and fresh-frozen plasma

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Standard haemostatic tests following major obstetric haemorrhage

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The Coagulopathy of Chronic Liver Disease

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The desperate need for good-quality clinical trials to evaluate the optimal source and dose of fibrinogen in managing bleeding

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The impact of fresh frozen plasma vs coagulation factor concentrates on morbidity and mortality in trauma-associated haemorrhage and massive transfusion. Injury

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Thrombelastography (TEG) or thromboelastometry (ROTEM) to monitor haemotherapy versus usual care in patients with massive transfusion (Review)

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Whole blood thromboelastometry: another Knight at the Roundtable?

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A critical evaluation of cryoprecipitate for replacement of fibrinogen

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Goal-directed coagulation management of majot trauma patients using thromboelastometry (ROTEM©)-guidedadminisrtation of fibrinogen concentrates and prothrombin complex concentrates

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Use of rotation thrombelastometry (ROTEM) to achieve successful treatment of of polytrauma with fibrinogen concentrate and prothrombin complex concentrate.

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Anesthesia 2010 65(2) 199-203

An assessment of cardiopulmonary bypass-induced changes in platelet function using whole blood and classical light transmission aggregometry: the results of a pilot study.

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Bleeding management with fibrinogen concentrate targeting a high-normal plasma fibrinogen level: a pilot study

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British Journal of Anaesthesia 2009 110(2) 212-213

Blood Coagulation: Hemostasis and Thrombin Regulation

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Coagulopathy during Induced Severe Intracranial Hypertension in a Porcine Donor Model

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Detection of Protamine and Heparin After Termination of Cardiopulmonary Bypass by Thrombelastometry (ROTEM©): Results of a Pilot Study

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Excessive Perioperative Bleeding: Are Fibrin Monomers and Factor XIII the Missing Link?

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Factor XIII Substitution in Surgical Cancer Patients at High Risk for Intraoperative Bleeding

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Fibrinogen substitution improves whole blood clot firmness following dilution with hydroxyethyl starch in bleeding patients undergoing radical cystectomy - a randomised placebo-controlled clinical trial

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Finding the optimal concentration range for fibrinogen replacement after severe haemodilution: an in vitro model

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Rapidly degradable hydroxyethyl starch solutions impair blood coagulation after cardiac surgery: a prospective randomized trial.

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The Effects of Fibrinogen Levels on Thromboelastometric Variables in the Presence of Thrombocytopenia

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Transfusion in trauma: why and how should we change our current practice?

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